el-Attar A M
King Faisal University, King Fahd University Hospital, Al-Khobar.
Anaesthesia. 1991 Dec;46(12):1059-63. doi: 10.1111/j.1365-2044.1991.tb09924.x.
Twenty-six patients undergoing middle ear surgery were anaesthetised using a completely closed circuit into which liquid isoflurane was injected using a syringe pump. The injection rate was guided by a table of calculated rates of isoflurane uptake, utilising the square root of time principle, at succeeding time intervals in different weight groups. A constant alveolar concentration of 1.3 MAC was aimed for. The injection rate was changed to that for the higher or lower weight group appropriate to the time interval whenever clinical signs indicated inappropriate depth of anaesthesia. A mean of 10.3 ml liquid isoflurane was used to maintain anaesthesia for a mean of 82.3 minutes. Blood pressure was maintained at 75% of the pre-operative value. Mean arterial blood gas data and changes in plasma catecholamine levels were within the normal range. The mean recovery time was 10.5 minutes. Syringe pump delivery of liquid isoflurane avoided fluctuations that result from bolus injections of unit dose. The implemented injection rate table, working as a therapeutic window, guided redosing, reduced calculation time and served as a record. The technique is safe, economic and adaptable to variations in uptake and response to inhalational anaesthetics.
26例接受中耳手术的患者采用完全封闭回路麻醉，通过注射泵向回路中注入液体异氟烷。注射速率根据异氟烷摄取率计算表指导，利用时间平方根原理，在不同体重组的后续时间间隔进行。目标是维持恒定的肺泡浓度为1.3MAC。每当临床体征表明麻醉深度不合适时，将注射速率改为适合该时间间隔的较高或较低体重组的速率。平均使用10.3ml液体异氟烷维持麻醉82.3分钟。血压维持在术前值的75%。平均动脉血气数据和血浆儿茶酚胺水平变化在正常范围内。平均恢复时间为10.5分钟。注射泵输送液体异氟烷避免了单位剂量推注引起的波动。实施的注射速率表作为一个治疗窗口，指导再次给药，减少计算时间并作为记录。该技术安全、经济，适用于吸入麻醉药摄取和反应的变化。
