de Kozak Y, Ardy H, Tuyen V V, Thillaye B, Faure J P
Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):233-6.
EAU is induced in guinea pigs by one inoculation into the foot-pad of a retinal extract in complete Freund's adjuvant. The evolution of the antibodies (complement fixation) is compared with the évolution of the disease (intensity evaluated by frequent ophthalmological examinations). The successful passive transfer of the disease by local injections of immune serum and the demonstration by immunofluorescence of immune complexes in the ocular tissues are arguments for the role of humoral antibodies in the induction of the disease. EAUmay be inhibited by repeated subcutaneous or intradermal injections of the antigen, either before or after the onset of the inflammation. These injections depress the delayed hypersensitivity and increase the titre of complement fixing and passive anaphylactic antibodies.
通过在豚鼠脚垫中单次注射完全弗氏佐剂中的视网膜提取物来诱导实验性自身免疫性葡萄膜炎（EAU）。将抗体（补体结合）的演变与疾病的演变（通过频繁的眼科检查评估强度）进行比较。通过局部注射免疫血清成功地被动转移疾病，以及通过免疫荧光在眼组织中证明免疫复合物，这些都是体液抗体在疾病诱导中起作用的证据。在炎症发作之前或之后，通过反复皮下或皮内注射抗原，EAU可能会受到抑制。这些注射会抑制迟发型超敏反应，并增加补体结合抗体和被动过敏抗体的滴度。
