King J C, Lichenstein R, Feigelman S, Luna C, Permutt T J, Patel J
Department of Pediatrics, University of Maryland School of Medicine, Baltimore.
Am J Dis Child. 1993 May;147(5):558-60. doi: 10.1001/archpedi.1993.02160290064027.
To determine quantitative measles, mumps, and rubella serum antibody levels as a function of time since vaccination in a sample of vaccinated Baltimore children.
Cross-sectional serologic survey.
Pediatric outpatient departments at the University of Maryland Medical Center, Baltimore.
One hundred seventy children, ranging in age from 1.5 through 16 years, who had measles, mumps, and rubella vaccination between ages 12 and 18 months.
Serum antibody levels to measles and rubella declined with increasing time since vaccination. However, no such decline in antibody levels to mumps was observed. Children who were vaccinated between ages 12 and 14 months did not have lower antibody levels than children who were vaccinated at age 15 months or older.
In areas free from natural disease, antibody levels resultant from measles, mumps, and rubella vaccine are likely to decline with advancing age. Revaccination with measles, mumps, and rubella vaccine may boost falling antibody titers.
在一组接种过疫苗的巴尔的摩儿童样本中，确定麻疹、腮腺炎和风疹血清抗体水平随接种疫苗后的时间变化情况。
横断面血清学调查。
巴尔的摩马里兰大学医学中心的儿科门诊。
170名年龄在1.5岁至16岁之间的儿童，他们在12至18个月大时接种过麻疹、腮腺炎和风疹疫苗。
麻疹和风疹的血清抗体水平随着接种疫苗后时间的增加而下降。然而，未观察到腮腺炎抗体水平有此类下降。12至14个月大时接种疫苗的儿童，其抗体水平并不低于15个月及以上接种疫苗的儿童。
在无自然疾病的地区，麻疹、腮腺炎和风疹疫苗产生的抗体水平可能会随着年龄增长而下降。再次接种麻疹、腮腺炎和风疹疫苗可能会提高下降的抗体滴度。
