导尿管相关菌尿的抗菌预防
Antimicrobial prophylaxis for catheter-associated bacteriuria.
作者信息
Britt M R, Garibaldi R A, Miller W A, Hebertson R M, Burke J P
出版信息
Antimicrob Agents Chemother. 1977 Feb;11(2):240-3. doi: 10.1128/AAC.11.2.240.
We evaluated short-term systemic antimicrobial prophylaxis for catheter-associated bacteriuria in women undergoing elective gynecological operations in a prospective, controlled, double-masked study. Nine of 100 placebo-treated patients acquired bacteriuria during catheterization compared with 3 of 96 of the drug-treated group. However, at the time of hospital discharge, clean-voided urine specimens were positive as frequently in the drug-treated group (8 of 82 patients cultured) as in the placebo group (8 of 75 patients cultured). No difference in febrile morbidity due to bacteriuria was noted between the prophylaxis and placebo groups. The incidence of catheter-associated bacteriuria may be reduced by antimicrobial prophylaxis. However, because the protective effect is transient and is associated with the selection of resistant organisms, prophylaxis is not indicated for patients at low risk for acquired bacteriuria and in whom the sequelae of catheter-associated infections are infrequent.
在一项前瞻性、对照、双盲研究中，我们评估了短期全身性抗菌药物预防对择期妇科手术女性导管相关菌尿症的效果。100名接受安慰剂治疗的患者中有9名在导尿期间发生菌尿症，而药物治疗组96名患者中有3名发生菌尿症。然而，在出院时，清洁中段尿标本在药物治疗组（82名培养患者中有8名）和安慰剂组（75名培养患者中有8名）中阳性的频率相同。预防组和安慰剂组之间因菌尿症导致的发热发病率没有差异。抗菌药物预防可能会降低导管相关菌尿症的发生率。然而，由于保护作用是短暂的，并且与耐药菌的选择有关，对于获得性菌尿症低风险且导管相关感染后遗症不常见的患者，不建议进行预防。
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