Liu M, Chino N, Ishihara T
Department of Rehabilitation Medicine, Higashisaitama National Hospital, Saitama, Japan.
Arch Phys Med Rehabil. 1993 May;74(5):507-14. doi: 10.1016/0003-9993(93)90115-q.
The progression of muscle damage was studied in the lower extremity and trunk muscles of patients with Duchenne muscular dystrophy (DMD) with a new quantitative computed tomography (CT) method. The degree of muscle fiber loss and fat tissue replacement was quantified using the indices of percent cross-sectional area (%CSA) of muscle and fat, or the percentages of the area having the CT numbers of normal muscle and fat. A cross-sectional study in 71 patients showed that as the disability stage progressed, both CT number and %CSA of muscle decreased while %CSA of fat increased. The rate of progression was different for each muscle, and the order of involvement was clarified. The CT findings were also significantly correlated with muscle strength, indicating validity of our method. Our findings of the natural course of muscle involvement would be useful in providing appropriate rehabilitative care as well as assessing the efficacy of therapeutic interventions.
采用一种新的定量计算机断层扫描（CT）方法，对杜氏肌营养不良症（DMD）患者的下肢和躯干肌肉的损伤进展情况进行了研究。利用肌肉和脂肪的横截面积百分比（%CSA）指数，或具有正常肌肉和脂肪CT值区域的百分比，对肌纤维损失程度和脂肪组织替代情况进行了量化。对71例患者的横断面研究表明，随着残疾阶段的进展，肌肉的CT值和%CSA均降低，而脂肪的%CSA增加。每块肌肉的进展速度不同，受累顺序得以明确。CT检查结果也与肌肉力量显著相关，表明我们的方法具有有效性。我们关于肌肉受累自然病程的研究结果，将有助于提供适当的康复护理以及评估治疗干预措施的疗效。
