Emerson P, Fujimura M, Howat P, Howes D, Keeling J, Robinson R O, Salisbury D, Tizard J P
Arch Dis Child. 1977 Mar;52(3):183-7. doi: 10.1136/adc.52.3.183.
The detection of the onset of intraventricular haemorrhage (IVH) during life is a necessary preliminary to understanding the cause of this condition. In 10 infants of very low birthweight treated with serial transfusions of adult blood the proportions of transfused cells circulating after each transfusion were compared with the proportion of transfused cells found in the intraventricular clot at necropsy. This allowed the timing of IVH to be restricted retrospectively to the period between consecutive blood transfusions. In addition, the proportional changes of transfused cells produced by infusion of a known red cell mass allow changes in the babies' original red cell mass to be followed during life. A fall in this value occurred in 8 infants dying with IVH and was taken to indicate haemorrhage. Comparison of the two methods in 9 infants suggested that, while in some cases intraventricular bleeding occurs rapidly, in others it takes place over a period of time. The interval between birth and the onset of haemorrhage was directly proportional to the gestational age of the infant.
在婴儿存活期间检测脑室内出血（IVH）的发病情况是了解该病症病因的必要前提。在10名极低出生体重儿接受成人血液的系列输血治疗后，将每次输血后循环的输血细胞比例与尸检时在脑室内凝块中发现的输血细胞比例进行比较。这使得IVH的发病时间能够追溯性地限定在连续输血之间的时间段内。此外，通过输注已知红细胞量所产生的输血细胞比例变化，可以追踪婴儿在存活期间原始红细胞量的变化。8例死于IVH的婴儿出现了该值下降，这被视为出血的指征。对9名婴儿的两种方法进行比较表明，虽然在某些情况下脑室内出血迅速发生，但在其他情况下则会持续一段时间。出生与出血发病之间的间隔与婴儿的胎龄成正比。
