Bucx M J, Kroon J W, Stienstra R
Department of Anesthesiology, Erasmus University Rotterdam, The Netherlands.
Reg Anesth. 1993 Mar-Apr;18(2):103-5.
The aim of this study was to investigate if a ten-fold difference in speed of injection of a plain solution of bupivacaine 0.5% at room temperature into the subarachnoid space would result in a temperature-dependent change in baricity large enough to be reflected in a significant difference between the maximum levels of sensory blockade.
In this prospective study, 40 male patients were randomly assigned to one of two groups. Group 1 patients received 3 ml plain bupivacaine 0.5% (20-22 degrees C) with the speed of injection as fast as possible. Group 2 patients received 3 ml plain bupivacaine 0.5% (20-22 degrees C) at a rate of 0.05 ml/sec. Thirty minutes after subarachnoid injection the maximum level of sensory blockade was determined by pinprick in the anterior axillary line by a blinded observer.
The mean maximum level of sensory blockade in patients of group 1 was T7.5 (median, T7; range, T3-12) and in group 2 patients T6.4 (median, 5.5; range, T3-11), the difference not being statistically significant (p > 0.05).
There is no clinically relevant influence on the maximum level of sensory blockade when bupivacaine 0.5% at room temperature is injected with a ten-fold difference in speed.
本研究旨在调查在室温下将0.5%布比卡因的普通溶液以10倍的注射速度差异注入蛛网膜下腔，是否会导致比重随温度变化，且变化幅度大到足以在感觉阻滞的最大水平上体现出显著差异。
在这项前瞻性研究中，40例男性患者被随机分为两组。第1组患者接受3毫升0.5%布比卡因普通溶液（20 - 22摄氏度），注射速度尽可能快。第2组患者接受3毫升0.5%布比卡因普通溶液（20 - 22摄氏度），注射速度为0.05毫升/秒。蛛网膜下腔注射30分钟后，由一位不知情的观察者通过针刺腋前线来确定感觉阻滞的最大水平。
第1组患者感觉阻滞的平均最大水平为T7.5（中位数，T7；范围，T3 - 12），第2组患者为T6.4（中位数，5.5；范围，T3 - 11），差异无统计学意义（p > 0.05）。
当室温下的0.5%布比卡因以10倍的速度差异进行注射时，对感觉阻滞的最大水平没有临床相关影响。
