Stienstra R, van Poorten J F
Department of Anesthesiology, Reinier de Graaf Gasthius, Delft, The Netherlands.
Anesth Analg. 1988 Mar;67(3):272-6.
Three milliliters of plain bupivacaine 0.5% was injected intrathecally in two groups of 20 patients. Group 1 received a solution that had been equilibrated to 37 degrees C, group 2 received a solution that had been equilibrated to 4 degrees C. Patients were kept sitting for 3 minutes after injection. All observations were observer-blind. The differences between segmental levels of sensory loss between groups 1 and 2 (T4 and T9, respectively) and of temperature loss (T3 and T8, respectively) 10 and 20 minutes after injection of bupivacaine were statistically significant. It is concluded that the time needed for thermal equilibration in the cerebrospinal fluid and hence temperature of the injected solution plays an important role in the sensory spread of plain bupivacaine 0.5%.
将3毫升0.5%的普通布比卡因经鞘内注射到两组各20例患者体内。第一组接受已平衡至37摄氏度的溶液，第二组接受已平衡至4摄氏度的溶液。注射后患者保持坐姿3分钟。所有观察均为观察者盲法。注射布比卡因后10分钟和20分钟，两组之间感觉丧失节段水平（分别为T4和T9）和温度丧失（分别为T3和T8）的差异具有统计学意义。得出结论：脑脊液中热平衡所需时间以及注射溶液的温度在0.5%普通布比卡因的感觉扩散中起重要作用。
