宫内暴露于抗惊厥药物后的新生儿低钙血症。
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
作者信息
Friis B, Sardemann H
出版信息
Arch Dis Child. 1977 Mar;52(3):239-41. doi: 10.1136/adc.52.3.239.
Abstract
Two cases are reported of prolonged hypocalcaemia with tetany in infants born at term, whose mothers had been treated with phenytoin and phenobarbitone in high doses. Both infants presented with jitteriness and tetany in the first and second weeks of life, and in both the hypocalcaemia was resistant to therapy over a longer period. An effect on the fetal vitamin D metabolism by phenytoin and phenobarbitone, resulting in defective bone mineralization and neonatal hypocalcaemia is suggested.
摘要
报道了两例足月出生的婴儿出现长时间低钙血症并伴有手足搐搦的病例，其母亲在孕期曾大剂量使用苯妥英钠和苯巴比妥。两名婴儿均在出生后的第一周和第二周出现易激惹和手足搐搦症状，且两人的低钙血症在较长一段时间内对治疗均有抵抗。提示苯妥英钠和苯巴比妥对胎儿维生素D代谢有影响，导致骨矿化缺陷和新生儿低钙血症。
相似文献
1
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.宫内暴露于抗惊厥药物后的新生儿低钙血症。
Arch Dis Child. 1977 Mar;52(3):239-41. doi: 10.1136/adc.52.3.239.
2
Loss of seizure control due to anticonvulsant-induced hypocalcemia.抗惊厥药引起的低钙血症导致癫痫控制丧失。
Ann Pharmacother. 2004 Jun;38(6):1002-5. doi: 10.1345/aph.1D467. Epub 2004 Apr 14.
3
Anticonvulsant hypocalcaemia.抗惊厥药所致低钙血症
Br Med J. 1972 Jun 24;2(5816):768-9. doi: 10.1136/bmj.2.5816.768-c.
4
Disturbance of calcium metabolism by anticonvulsant drugs.抗惊厥药物对钙代谢的干扰。
Br Med J. 1970 Oct 10;4(5727):73-6. doi: 10.1136/bmj.4.5727.73.
5
Fetal phenytoin exposure, hypoplastic nails, and jitteriness.胎儿期暴露于苯妥英、指甲发育不全与易激惹。
Arch Dis Child. 1991 Mar;66(3):320-4. doi: 10.1136/adc.66.3.320.
6
Functional palatal incompetence in the fetal anticonvulsant syndrome.胎儿抗惊厥综合征中的功能性腭功能不全。
Arch Dis Child. 1984 Oct;59(10):989-90. doi: 10.1136/adc.59.10.989.
7
Stevens-Johnson syndrome associated with anticonvulsant therapy in a neonate.
Clin Pharm. 1982 Nov-Dec;1(6):565-7.
8
Magnesium therapy in neonatal tetany.新生儿手足搐搦症的镁剂治疗
Lancet. 1977 Feb 5;1(8006):283-4. doi: 10.1016/s0140-6736(77)91826-8.
9
Neonatal hypocalcemia.
N Engl J Med. 1968 Aug 8;279(6):327.
10
Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy.
J Fam Pract. 1984 Jun;18(6):873-7.
引用本文的文献
1
Transposition of the great arteries and hypocalcemia in a patient with fetal hydantoin syndrome.一名患有胎儿妥英综合征的患者出现大动脉转位和低钙血症。
J Perinatol. 2002 Jan;22(1):89-90. doi: 10.1038/sj.jp.7210596.
2
Drug-induced electrolyte abnormalities.药物性电解质异常
Drugs. 1982 Sep;24(3):207-28. doi: 10.2165/00003495-198224030-00002.
本文引用的文献
1
Diphenylhydantoin: placental transport, fetal localization, neonatal metabolism, and possible teratogenic effects.
J Pediatr. 1971 Feb;78(2):329-37. doi: 10.1016/s0022-3476(71)80025-2.
2
Human perinatal vitamin D metabolism. I. 25-Hydroxyvitamin D in maternal and cord blood.人类围产期维生素D代谢。I. 母血和脐血中的25-羟基维生素D。
J Pediatr. 1974 May;84(5):742-9. doi: 10.1016/s0022-3476(74)80024-7.
3
Neonatal hypocalcaemia. "Early type" in low birth weight newborns.新生儿低钙血症。低出生体重新生儿的“早发型”
Helv Paediatr Acta. 1973 Nov;28(5):443-57.
4
Calcium metabolism in pregnancy and in the newborn.妊娠及新生儿期的钙代谢
J Obstet Gynaecol Br Commonw. 1974 Mar;81(3):210-9. doi: 10.1111/j.1471-0528.1974.tb00447.x.
5
"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.
Br Med J. 1974 May 4;2(5913):258-9. doi: 10.1136/bmj.2.5913.258.
6
Effects of long-term anticonvulsant therapy on calcium and vitamin D metabolism.长期抗惊厥治疗对钙和维生素D代谢的影响。
Proc R Soc Med. 1974 Jan;67(1):64-8. doi: 10.1177/003591577406700146.
Zotero 插件