Friis B, Sardemann H
Arch Dis Child. 1977 Mar;52(3):239-41. doi: 10.1136/adc.52.3.239.
Two cases are reported of prolonged hypocalcaemia with tetany in infants born at term, whose mothers had been treated with phenytoin and phenobarbitone in high doses. Both infants presented with jitteriness and tetany in the first and second weeks of life, and in both the hypocalcaemia was resistant to therapy over a longer period. An effect on the fetal vitamin D metabolism by phenytoin and phenobarbitone, resulting in defective bone mineralization and neonatal hypocalcaemia is suggested.
报道了两例足月出生的婴儿出现长时间低钙血症并伴有手足搐搦的病例，其母亲在孕期曾大剂量使用苯妥英钠和苯巴比妥。两名婴儿均在出生后的第一周和第二周出现易激惹和手足搐搦症状，且两人的低钙血症在较长一段时间内对治疗均有抵抗。提示苯妥英钠和苯巴比妥对胎儿维生素D代谢有影响，导致骨矿化缺陷和新生儿低钙血症。
