Clarke M, Mason E S, MacVicar J, Clayton D G
Department of Epidemiology and Public Health, University of Leicester, Leicester Royal Infirmary.
BMJ. 1993 Mar 27;306(6881):824-7. doi: 10.1136/bmj.306.6881.824.
To evaluate perinatal mortality rates as a method of auditing obstetric and neonatal care after account had been taken of transfer between hospitals during pregnancy and case mix.
Case-control study of perinatal deaths.
Leicestershire health district.
1179 singleton perinatal deaths and their selected live born controls among 114,362 singleton births to women whose place of residence was Leicestershire during 1978-87.
Crude perinatal mortality rates and rates adjusted for case mix.
An estimated 11,701 of the 28,750 women booked for delivery in general practitioner maternity units were transferred to consultant units during their pregnancy. These 11,701 women had a high perinatal mortality rate (16.8/1000 deliveries). Perinatal mortality rates by place of booking showed little difference between general practitioner units (8.8/1000) and consultant units (9.3-11.7/1000). Perinatal mortality rates by place of delivery, however, showed substantial differences between general practitioner units (3.3/1000) and consultant units (9.4-12.6/1000) because of the selective referral of high risk women from general practitioner units to consultant units. Adjustment for risk factors made little difference to the rates except when the subset of deaths due to immaturity was adjusted for birth weight.
Perinatal mortality rates should be adjusted for case mix and referral patterns to get a meaningful result. Even when this is done it is difficult to compare the effectiveness of hospital units with perinatal mortality rates because of the increasingly small subset of perinatal deaths that are amenable to medical intervention.
在考虑孕期医院间转诊及病例组合情况后,评估围产期死亡率作为产科和新生儿护理审核方法的有效性。
围产期死亡病例对照研究。
莱斯特郡卫生区。
1978 - 1987年期间,居住在莱斯特郡的妇女所生的114,362例单胎分娩中,1179例单胎围产期死亡病例及其选定的存活对照。
粗围产期死亡率及经病例组合调整后的死亡率。
预计在全科医生产科单位预约分娩的28,750名妇女中,有11,701名在孕期被转诊至专科医生单位。这11,701名妇女的围产期死亡率较高(16.8/1000次分娩)。按预约地点划分的围产期死亡率在全科医生单位(8.8/1000)和专科医生单位(9.3 - 11.7/1000)之间差异不大。然而,按分娩地点划分的围产期死亡率在全科医生单位(3.3/1000)和专科医生单位(9.4 - 12.6/1000)之间存在显著差异,这是因为高危妇女从全科医生单位选择性转诊至专科医生单位。除了对因不成熟导致的死亡子集按出生体重进行调整外,对危险因素的调整对死亡率影响不大。
围产期死亡率应根据病例组合和转诊模式进行调整,以获得有意义的结果。即便如此,由于可通过医疗干预降低的围产期死亡子集越来越小,很难根据围产期死亡率比较医院单位的医疗效果。