关于呋喃甾族糖苷强心作用的一些药理学研究。
Some pharmacological studies on the cardiotonic effects of furanosteroidal glycosides.
作者信息
Matsumura S, Kimoto S, Uno O, Minesita T, Ueda M
出版信息
Arch Int Pharmacodyn Ther. 1977 Feb;225(2):246-56.
Cardiotonic effects and cardiotoxicities of three furanosteroidal glycosides were compared with those of standard cardiac glycosides (digitoxin, gitoxin, etc.). Furanosteroidal glycosides showed positive inotropic effects in both isolated guinea-pig atria and rabbit hearts. The positive inotropic effect of 17beta-(3-furyl)-5beta,14beta-androstane-3beta,14,16beta-triol-3-bisdigitoxoside(FGBD) corresponded to that of digitoxin in isolated guinea-pig atria and frog hearts. Intravenous and oral administration of FGBD and 17beta-(3-furyl)-5beta,14beta-androstane-3beta,14,16beta-triol-3-tridigitoxoside(FGTD) in higher doses induced cardiac arrest after vomiting, bradycardia, ventricular rhythm, and ventricular fibrillation in pigeons and cats. Comparison of lethal doses between intravenous and oral administration of cardiac glycosides in pigeons and cats suggested that gastrointestinal absorption of FGBD and FGTD is inferior to that of digitoxin but superior to that of gitoxigenin bisdigitoxoside and gitoxin. Cardiotonic effects of furanosteroidal glycosides were confirmed in isolated guinea-pig, rabbit and frog hearts.
比较了三种呋喃甾类糖苷与标准强心苷（洋地黄毒苷、吉托辛等）的强心作用和心脏毒性。呋喃甾类糖苷在离体豚鼠心房和兔心脏中均表现出正性肌力作用。17β-(3-呋喃基)-5β,14β-雄甾烷-3β,14,16β-三醇-3-双洋地黄毒糖苷（FGBD）在离体豚鼠心房和蛙心脏中的正性肌力作用与洋地黄毒苷相当。静脉注射和口服较高剂量的FGBD和17β-(3-呋喃基)-5β,14β-雄甾烷-3β,14,16β-三醇-3-三洋地黄毒糖苷（FGTD）后，鸽子和猫出现呕吐、心动过缓、室性节律和心室颤动，随后心脏骤停。比较鸽子和猫静脉注射和口服强心苷的致死剂量表明，FGBD和FGTD的胃肠道吸收比洋地黄毒苷差，但优于吉托皂苷元双洋地黄毒糖苷和吉托辛。呋喃甾类糖苷的强心作用在离体豚鼠、兔和蛙心脏中得到证实。
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