Neugut A I, Robinson E, Lee W C, Murray T, Karwoski K, Kutcher G J
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Cancer. 1993 May 15;71(10):3054-7. doi: 10.1002/1097-0142(19930515)71:10<3054::aid-cncr2820711027>3.0.co;2-n.
Radiation, including radiation therapy (RT) for a variety of conditions, is known to be a lung carcinogen.
Data from the Surveillance, Epidemiology, and End Results program of the National Cancer Institute for 1973-1986 were utilized to investigate whether RT for breast cancer affects the risk of subsequent lung cancer. The relative risk was calculated by comparing the incidence rate in patients with irradiated breast cancer with that in those with nonirradiated breast cancer.
It was found that the risk of lung cancer overall was increased in women who underwent irradiation compared with those who were not irradiated 10 years after the initial breast cancer diagnosis with a relative risk of 2.0 (95% confidence interval, 1.0-4.3). In addition, the risk of lung cancer was in the ipsilateral lung compared with the contralateral lung for irradiated women. This increase was observed after 10 years for lung cancer overall and for the three major histologic subgroups (small cell, squamous cell, and adenocarcinoma). Specific information on RT doses and treatment plans and cigarette smoking were not available.
It was concluded that RT for breast cancer may increase the risk of lung cancer after a latency period of 10 years.
辐射，包括针对各种病症的放射治疗（RT），已知是一种肺部致癌物。
利用美国国立癌症研究所监测、流行病学和最终结果计划1973 - 1986年的数据，调查乳腺癌放疗是否会影响后续患肺癌的风险。通过比较接受过放疗的乳腺癌患者与未接受放疗的乳腺癌患者的发病率来计算相对风险。
发现与初次诊断乳腺癌后未接受放疗的女性相比，接受放疗的女性在10年后患肺癌的总体风险增加，相对风险为2.0（95%置信区间，1.0 - 4.3）。此外，接受放疗的女性患肺癌的风险在同侧肺高于对侧肺。总体肺癌以及三个主要组织学亚组（小细胞癌、鳞状细胞癌和腺癌）在10年后都观察到了这种增加。关于放疗剂量、治疗方案和吸烟的具体信息不可得。
得出结论，乳腺癌放疗可能在10年潜伏期后增加患肺癌的风险。
