孕酮和雄激素对子宫内膜癌生长的影响。
The influence of progesterone and androgens on the growth of endometrial carcinoma.
作者信息
Boman K, Strang P, Bäckström T, Stendahl U
机构信息
Department of Gynecologic Oncology, University Hospital, Umeå, Sweden.
出版信息
Cancer. 1993 Jun 1;71(11):3565-9. doi: 10.1002/1097-0142(19930601)71:11<3565::aid-cncr2820711117>3.0.co;2-7.
BACKGROUND
The prognosis for endometrial cancer is correlated to the proliferative activity, expressed as the fraction of cells in the synthesis phase (S-phase fraction [SPF]). Progesterone has an antiproliferative effect on the normal endometrium. Its effect in endometrial adenocarcinoma has not been investigated in such detail.
METHODS
The SPF in tumor tissue and serum levels of progesterone, androstenedione, and testosterone were measured in 78 postmenopausal women with the diagnosis of endometrial adenocarcinoma.
RESULTS
No correlations were found between the SPF and androstenedione or testosterone level. No linear correlation between the progesterone concentration and the SPF was revealed when all the patients were analyzed. The material was then divided into subgroups according to the tumor grade and ploidy level. A stepwise analysis based on the progesterone concentration showed that, in well-differentiated and moderately differentiated tumors, the growth rate, expressed as the SPF, fell when progesterone reached a serum level above 0.8 nM.
CONCLUSIONS
Endogenous progesterone plays a role in the control of the tumor's proliferation activity and, consequently, might be significant in the prognosis.
背景
子宫内膜癌的预后与增殖活性相关，增殖活性以合成期细胞分数（S期分数[SPF]）表示。孕酮对正常子宫内膜有抗增殖作用。其在子宫内膜腺癌中的作用尚未得到如此详细的研究。
方法
对78例诊断为子宫内膜腺癌的绝经后妇女测量肿瘤组织中的SPF以及孕酮、雄烯二酮和睾酮的血清水平。
结果
未发现SPF与雄烯二酮或睾酮水平之间存在相关性。对所有患者进行分析时，未发现孕酮浓度与SPF之间存在线性相关性。然后根据肿瘤分级和倍体水平将材料分为亚组。基于孕酮浓度的逐步分析表明，在高分化和中分化肿瘤中，当孕酮血清水平高于0.8 nM时，以SPF表示的生长速率下降。
结论
内源性孕酮在控制肿瘤增殖活性中起作用，因此可能对预后有重要意义。
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