Martin E M, Robertson L C, Sorensen D J, Jagust W J, Mallon K F, Chirurgi V A
Department of Neurology, University of California-Davis.
J Clin Exp Neuropsychol. 1993 Mar;15(2):311-20. doi: 10.1080/01688639308402565.
Thirty-seven nondemented HIV-seropositive and 17 seronegative control subjects were administered the Sternberg speed of memory scanning task, a procedure frequently employed to study mental slowing in patients with subcortical dementing disorders. Experimental and control subjects did not differ in speed of memory scanning, as indexed by the slopes of set size-reaction time functions, nor on mean 0-intercepts for the RT functions, which index stimulus detection and motor response time. Intercept values were significantly greater for subjects with a positive alcohol abuse history and for subjects with greater self-reported depression, but slopes were not significantly correlated with substance abuse history or psychological distress. Cognitive slowing in early HIV-1 infection is not a nonspecific effect observed across all measures of information processing speed. Underlying component functions measured must be carefully considered when selecting reaction time tasks for study with HIV-seropositive subjects. The term "subcortical" dementia may be too general a descriptor, and RT task performance may provide an alternative basis for classification of dementia types.
对37名无痴呆的HIV血清阳性者和17名血清阴性对照者进行了斯滕伯格记忆扫描速度任务测试，该程序常用于研究皮质下痴呆症患者的思维迟缓。实验对象和对照对象在记忆扫描速度上没有差异，这由集合大小-反应时间函数的斜率来衡量，RT函数的平均0截距也无差异，0截距衡量的是刺激检测和运动反应时间。有酒精滥用史阳性的受试者和自我报告抑郁程度较高的受试者的截距值显著更大，但斜率与物质滥用史或心理困扰无显著相关性。早期HIV-1感染中的认知迟缓并非在所有信息处理速度测量中都能观察到的非特异性效应。在为HIV血清阳性受试者选择反应时间任务进行研究时，必须仔细考虑所测量的潜在组成功能。“皮质下”痴呆这一术语可能是一个过于笼统的描述，反应时间任务表现可能为痴呆类型的分类提供另一种依据。
