Fitzgibbon M L, Cella D F, Humfleet G, Griffin E, Sheridan K
Northwestern University Medical School, Chicago, IL.
Percept Mot Skills. 1989 Jun;68(3 Pt 2):1331-8. doi: 10.2466/pms.1989.68.3c.1331.
To examine neuropsychological deficits associated with the human immunodeficiency virus (HIV), 25 asymptomatic homosexual men and sexual partners of intravenous drug users and 25 seronegative homosexual men and nonhigh-risk heterosexuals were assessed on measures of fine motor control, visual scanning, attention, depression, and global psychological functioning. Analysis suggested that HIV infection is associated with reduced fine motor control. Seropositivity is associated with elevated depression and global psychological maladjustment. When depression and global adjustment were analyzed as covariates, motor slowing was evident in the seropositive group. These findings suggest an association between motor slowing and HIV infection in asymptomatic subjects and point to the necessity of measuring affect at least as a control variable. Further study is needed to determine whether the fine motor deficit evident in this sample is limited to distinct subgrouping of the over-all sample.
为了研究与人类免疫缺陷病毒（HIV）相关的神经心理学缺陷，对25名无症状的同性恋男性及静脉吸毒者的性伴侣，以及25名血清反应阴性的同性恋男性和非高危异性恋者进行了精细运动控制、视觉扫描、注意力、抑郁及整体心理功能等方面的评估。分析表明，HIV感染与精细运动控制能力下降有关。血清反应阳性与抑郁情绪升高及整体心理失调有关。当将抑郁和整体心理调适作为协变量进行分析时，血清反应阳性组出现了明显的运动迟缓。这些发现表明，无症状受试者的运动迟缓与HIV感染之间存在关联，并指出至少应将情感作为控制变量进行测量的必要性。需要进一步研究来确定该样本中明显的精细运动缺陷是否仅限于总体样本的特定亚组。
