Appen R E, Roth H, ZuRhein G M, Varakis J N
Arch Ophthalmol. 1977 Apr;95(4):656-9. doi: 10.1001/archopht.1977.04450040122019.
A patient had been treated for chronic lymphocytic leukemia for five years before developing visual blurring as the manifestation of occipital lobe lesions of progressive multifocal leukoencephalopathy (PML). The disease is caused by an infection of the CNS oligodendrocytes by a papovavirus, whose replication is facilitated by an impairment of the host's cell-mediated immunologic system. The multiplying virus destroys the oligodendrocytes and causes extensive demyelination of the white matter of the brain. Antiviral agents, such as cytarabine, may be beneficial in treating patients with PML.
一名患者在因进行性多灶性白质脑病（PML）枕叶病变出现视力模糊之前，已接受慢性淋巴细胞白血病治疗五年。该疾病由一种乳头多瘤空泡病毒感染中枢神经系统少突胶质细胞引起，宿主细胞介导的免疫系统受损会促进该病毒的复制。不断增殖的病毒会破坏少突胶质细胞，并导致大脑白质广泛脱髓鞘。抗病毒药物，如阿糖胞苷，可能对治疗PML患者有益。
