Mathews T, Wisotzkey H, Moossy J
Neurology. 1976 Jan;26(1):9-14. doi: 10.1212/wnl.26.1.9.
Clinical, pathologic, and immunologic features of two patients with progressive multifocal leukoencephalopathy and multiple coexisting central nervous system infections are presented. Both showed impaired cell-mediated immunity whereas immunoglobulins were normal, suggesting that defective cellular rather than humoral immunity predisposes to progressive multifocal leukoencephalopathy. Continued neurologic deterioration might be due not only to progression of the condition but also to simultaneous opportunistic bacterial and fungal infections that may be amenable to treatment. Unusual features in case 1 included striking neurologic remission for 8 months and a positive brain scan corresponding to a large demyelinated lesion in the frontal lobe.
本文介绍了两名患有进行性多灶性白质脑病并伴有多种中枢神经系统感染的患者的临床、病理和免疫特征。两名患者均表现出细胞介导免疫功能受损，而免疫球蛋白正常，这表明细胞免疫缺陷而非体液免疫缺陷易导致进行性多灶性白质脑病。持续的神经功能恶化可能不仅是由于病情进展，还可能是由于同时存在的机会性细菌和真菌感染，而这些感染可能是可以治疗的。病例1的不寻常特征包括8个月的显著神经功能缓解以及与额叶一个大的脱髓鞘病变相对应的脑部扫描阳性结果。
