Michelson J B, Felberg N T, Shields J A
Arch Ophthalmol. 1977 Apr;95(4):692-4. doi: 10.1001/archopht.1977.04450040158025.
Plasma carcinoembryonic antigen (CEA) and gamma glutamyl transpeptidase (GTP) were studied in 24 patients with cancer metastatic to the uveal tract. Eighty-three percent demonstrated elevated CEA levels, while only 36% (49 of 135 patients) with primary uveal melanoma showed elevated levels. While none of the uveal melanoma patients had a CEA value greater than 10 ng/ml, 58% (14) of the patients with metastatic tumors to the uvea had values greater than 10 ng/ml. Forty-six percent (11) of patients with metastatic tumors to the uvea demonstrated elevated GTP levels that correlated with documentation of liver metastases. Ninety-two percent of the patients with metastatic cancer to the uvea had either an elevated CEA or GTP level. When used together, plasma CEA and GTP levels appear to be helpful in differentiating metastatic tumors to the uvea from primary uveal melanomas. These assays also appear to be useful in determining tumor burden and concurrent hepatic involvement in patients with metastatic tumors to the uvea.
对24例葡萄膜转移癌患者的血浆癌胚抗原（CEA）和γ-谷氨酰转肽酶（GTP）进行了研究。83%的患者CEA水平升高，而原发性葡萄膜黑色素瘤患者中只有36%（135例中的49例）CEA水平升高。虽然葡萄膜黑色素瘤患者的CEA值均未超过10 ng/ml，但58%（14例）葡萄膜转移瘤患者的CEA值超过10 ng/ml。46%（11例）葡萄膜转移瘤患者的GTP水平升高，这与肝转移的记录相关。92%的葡萄膜转移癌患者CEA或GTP水平升高。血浆CEA和GTP水平联合使用时，似乎有助于区分葡萄膜转移瘤和原发性葡萄膜黑色素瘤。这些检测方法似乎也有助于确定葡萄膜转移瘤患者的肿瘤负荷和同时存在的肝脏受累情况。
