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对肺癌脉络膜转移的全面认识。

A Comprehensive Understanding of Choroidal Metastasis from Lung Cancer.

作者信息

Qu Zihan, Liu Jiewei, Zhu Lingling, Zhou Qinghua

机构信息

Lung Cancer Center, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

出版信息

Onco Targets Ther. 2021 Aug 12;14:4451-4465. doi: 10.2147/OTT.S315532. eCollection 2021.

Abstract

The incidence of lung cancer with intraocular metastasis is low, of which choroidal metastasis is the most painful metastatic lesion. The clinical symptoms resulting from choroidal metastasis from lung cancer easily detected although they are rarely identified prior to the diagnosis of the primary malignancy. The quality of life of patients is inevitably impaired. Some lung cancer patients complain of ocular symptoms as the first manifestation of lung cancer. Early diagnosis and treatment can significantly overcome or delay the visual impairment and improve prognosis. The main therapeutic modalities include systemic and local treatments, while observation is also a treatment option. Currently, the feasibility and effectiveness of various treatment options are controversial worldwide. Herein, we summarize the underlying mechanisms, epidemiology, clinical features, auxiliary examinations, diagnosis, and recent treatment options for intraocular metastases.

摘要

肺癌眼内转移的发生率较低,其中脉络膜转移是最痛苦的转移病灶。肺癌脉络膜转移引起的临床症状虽在原发性恶性肿瘤诊断之前很少被识别,但很容易被检测到。患者的生活质量不可避免地受到损害。一些肺癌患者将眼部症状作为肺癌的首发表现。早期诊断和治疗可显著克服或延缓视力损害并改善预后。主要治疗方式包括全身和局部治疗,观察也是一种治疗选择。目前,各种治疗选择的可行性和有效性在全球范围内存在争议。在此,我们总结了眼内转移的潜在机制、流行病学、临床特征、辅助检查、诊断及近期治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2225/8367201/62fd307f2e7a/OTT-14-4451-g0001.jpg

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