Håkansson E M, Lundin L G
Biochem Genet. 1977 Feb;15(1-2):75-85. doi: 10.1007/BF00484549.
Activities of three lysosomal glycosidases, beta-galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase, have been shown to differ in bf/bf and bf/+ mice. Thus bf/bf mice usually have much higher activities of these enzymes in their kidney cells than bf/+ animals. There seem, however, to be some exceptions to this general pattern, especially for galactosidase of females from the C57BL/6J strain. A likely interpretation of the difference is that the bf locus has pleiotropic effects. An alternative explanation, less likely, is that a gene closely linked to bf is involved. There is also a differential response to dihydrotestosterone in different groups of mice reflected in activity changes of the three enzymes.
已证明三种溶酶体糖苷酶，即β-半乳糖苷酶、β-葡萄糖醛酸酶和N-乙酰-β-己糖胺酶的活性在bf/bf和bf/+小鼠中存在差异。因此，bf/bf小鼠肾细胞中这些酶的活性通常比bf/+动物高得多。然而，这种一般模式似乎存在一些例外，特别是对于C57BL/6J品系雌性小鼠的半乳糖苷酶。对这种差异的一种可能解释是bf基因座具有多效性。另一种不太可能的解释是与bf紧密连锁的一个基因参与其中。不同组小鼠对二氢睾酮也有不同反应，这在三种酶的活性变化中得到体现。
