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遗传因素对雄性小鼠肾脏葡萄糖醛酸酶活性的影响。

Genetic effects on male mouse kidney glucuronidase activity.

作者信息

Håkansson E M

出版信息

Biochem Genet. 1976 Oct;14(9-10):869-75. doi: 10.1007/BF00485348.

DOI:10.1007/BF00485348
PMID:1008808
Abstract

Kidney beta-glucuronidase activity in C57BL/K1 and DBA/2/K1 male mice differes about tenfold, C57 giving low and DBA high values. Another C57 subline, C57BL/6J, has slightly higher activity than C57BL/K1. There is an association between the kidney glucuronidase activity and coat color determined by the buff locus, which indicates that part of the variation is due to differences at the Gur locus. The bf allele per se raises the activity of the enzyme. The backcross distributions give evidence that at least one more locus is involved.

摘要

C57BL/K1和DBA/2/K1雄性小鼠的肾脏β-葡萄糖醛酸酶活性相差约10倍,C57的活性值低,DBA的活性值高。另一个C57亚系C57BL/6J的活性略高于C57BL/K1。肾脏葡萄糖醛酸酶活性与由浅黄色基因座决定的毛色之间存在关联,这表明部分变异是由于Gur基因座的差异所致。bf等位基因本身会提高该酶的活性。回交分布表明至少还有一个基因座参与其中。

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1
Genetic effects on male mouse kidney glucuronidase activity.遗传因素对雄性小鼠肾脏葡萄糖醛酸酶活性的影响。
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引用本文的文献

1
A gene affecting liver activities of three glycosidases in the house mouse.一个影响家鼠肝脏中三种糖苷酶活性的基因。
Biochem Genet. 1981 Jun;19(5-6):457-64. doi: 10.1007/BF00484618.
2
Relationship among H-2 type, serum testosterone level, and kidney beta-glucuronidase activity in the mouse.小鼠中H-2类型、血清睾酮水平与肾脏β-葡萄糖醛酸酶活性之间的关系。
Biochem Genet. 1976 Oct;14(9-10):771-6. doi: 10.1007/BF00485340.
3
Effect of a coat color locus on kidney lysosomal glycosidases in the house mouse.毛色基因座对家鼠肾脏溶酶体糖苷酶的影响。

本文引用的文献

1
Liver-glucuronidase activity of inbred mouse strains.近交系小鼠品系的肝脏葡萄糖醛酸酶活性。
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2
Beta-glucuronidase and the action of steroid hormones.β-葡萄糖醛酸酶与类固醇激素的作用
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Biochem Genet. 1977 Feb;15(1-2):75-85. doi: 10.1007/BF00484549.
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7
Lysosomal and microsomal glucuronidase: genetic variant alters electrophoretic mobility of both hydrolases.溶酶体和微粒体葡萄糖醛酸酶:基因变异改变了两种水解酶的电泳迁移率。
Science. 1974 Aug 2;185(4149):442-4.
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Genetic control of glucuronidase induction in mice.小鼠中葡萄糖醛酸酶诱导的遗传控制。
J Mol Biol. 1973 Dec 5;81(2):225-43. doi: 10.1016/0022-2836(73)90191-5.
9
Simple inheritance of variations in male mouse kidney beta-glucuronidase activity.雄性小鼠肾脏β-葡萄糖醛酸酶活性变异的简单遗传
Biochem Genet. 1973 Dec;10(4):333-40. doi: 10.1007/BF00485988.
10
Recombinant inbred lines: value in the genetic analysis of biochemical variants.重组近交系:在生化变异体遗传分析中的价值。
Science. 1973 Sep 28;181(4106):1249-52. doi: 10.1126/science.181.4106.1249.