心脏毒素、鱼精蛋白和聚赖氨酸的抗胆碱酯酶活性机制。
Mechanism of anticholinesterase activities of cardiotoxin, protamine and polylysine.
作者信息
Lin S Y, Liao C, Lee C Y
出版信息
Biochem J. 1977 Feb 1;161(2):229-32. doi: 10.1042/bj1610229.
Abstract
Cardiotoxin, protamine and polylysine are potent inhibitors of various cholinesterases. CaCl2 and MgCl2 overcome the inhibition. The order of addition of the inhibitor and the protecting agent (MgCl2) influences the final degree of the inhibition observed. These findings suggest that cardiotoxin, protamine and polylysine inhibit cholinesterases by the ionic binding of their basic groups with the anionic sites of cholinesterase molecules.
摘要
心脏毒素、鱼精蛋白和聚赖氨酸是多种胆碱酯酶的有效抑制剂。氯化钙和氯化镁可克服这种抑制作用。抑制剂和保护剂（氯化镁）的添加顺序会影响最终观察到的抑制程度。这些发现表明，心脏毒素、鱼精蛋白和聚赖氨酸通过其碱性基团与胆碱酯酶分子阴离子位点的离子结合来抑制胆碱酯酶。
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