分离出的类风湿因子与组蛋白和碱性聚阳离子的结合。
Binding of isolated rheumatoid factors to histone proteins and basic polycations.
作者信息
Hobbs R N, Lea D J, Phua K K, Johnson P M
出版信息
Ann Rheum Dis. 1983 Aug;42(4):435-8. doi: 10.1136/ard.42.4.435.
Abstract
A fluorimetric immunoassay has been used to assess reactivity of rheumatoid factor (RF) with both histone proteins and other basic polycations (poly-L-lysine, poly-L-ornithine, and protamine) bound to an immobilised tyrosine-glutamic acid polyanionic copolymer. Isolated RF preparations can bind to histone proteins in this assay, notably to H3 and H4 histones, and this activity was always masked in the original whole seropositive sera. Binding of isolated RF was often noted also to the other large-molecular-weight basic polycations.
摘要
一种荧光免疫测定法已被用于评估类风湿因子（RF）与组蛋白以及与固定化的酪氨酸-谷氨酸聚阴离子共聚物结合的其他碱性聚阳离子（聚-L-赖氨酸、聚-L-鸟氨酸和鱼精蛋白）的反应性。在该测定中，分离出的RF制剂可与组蛋白结合，特别是与H3和H4组蛋白结合，而这种活性在原始的全血清阳性血清中总是被掩盖。分离出的RF通常也会与其他大分子碱性聚阳离子结合。
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