钴对大鼠肝脏血红素合成的抑制作用。两个不同作用位点的证据。
Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.
作者信息
De Matteis F, Gibbs A H
出版信息
Biochem J. 1977 Jan 15;162(1):213-6. doi: 10.1042/bj1620213.
Abstract
Cobalt inhibits liver haem synthesis in vivo by acting at least two different sites in the biosynthetic pathway: (1) synthesis of 5-aminolaevulinate and (2) conversion of 5-amino-laevulinate into haem. The first effect is largely, if not entirely, due to inhibition of the activity of 5-aminolaevulinate synthase, rather than to inhibition of the formation of the enzyme. The second effect results from diversion of 5-aminolaevulinate into an unidentified liver pool with solubility properties similar to those of cobalt protoporphyrin.
摘要
钴在体内通过作用于生物合成途径中至少两个不同位点来抑制肝脏血红素的合成
（1）5-氨基酮戊酸的合成，以及（2）5-氨基酮戊酸向血红素的转化。第一种作用在很大程度上（如果不是完全的话）是由于抑制了5-氨基酮戊酸合酶的活性，而不是抑制该酶的形成。第二种作用是由于5-氨基酮戊酸转移到一个未明确的肝脏池，其溶解性与钴原卟啉相似。
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本文引用的文献
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The biological action of cobalt and other metals. II. The mechanism of the respiratory inhibition produced by cobalt in mammalian tissues.钴及其他金属的生物学作用。II. 钴在哺乳动物组织中产生呼吸抑制的机制。
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The role of adenosine triphosphate deficiency in ethionine-induced inhibition of protein synthesis.三磷酸腺苷缺乏在乙硫氨酸诱导的蛋白质合成抑制中的作用。
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A new method of hemin isolation.一种新的氯化血红素分离方法。
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