对氨基氧乙酸作为一种抑制剂的重新评估。
Re-evaluation of amino-oxyacetate as an inhibitor.
作者信息
Smith S B, Briggs S, Triebwasser K C, Freedland R A
出版信息
Biochem J. 1977 Feb 15;162(2):453-5. doi: 10.1042/bj1620453.
Abstract
Data are provided which indicate that pyruvate and/or acetaldehyde can reverse the inhibition of alanine aminotransferase and aspartate aminotransferase by amino-oxyacetate. It was shown that acetaldehyde could reverse the inhibition of gluconeogenesis from alanine and that pyruvate could reverse the inhibition of urea synthesis by amino-oxyacetate.
摘要
所提供的数据表明，丙酮酸和/或乙醛可以逆转氨基氧乙酸对丙氨酸转氨酶和天冬氨酸转氨酶的抑制作用。结果表明，乙醛可以逆转氨基氧乙酸对丙氨酸糖异生的抑制作用，而丙酮酸可以逆转氨基氧乙酸对尿素合成的抑制作用。
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本文引用的文献
1
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Biochem J. 1973 Jun;134(2):671-2. doi: 10.1042/bj1340671.
2
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
3
The pathway of gluconeogenesis in the cortex of guinea-pig kidney. Use of aminooxyacetate as a transaminase inhibitor.豚鼠肾皮质中糖异生的途径。使用氨基氧乙酸作为转氨酶抑制剂。
Eur J Biochem. 1972 Feb 15;25(2):366-71. doi: 10.1111/j.1432-1033.1972.tb01705.x.
4
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.大鼠肝脏实质细胞分离的高效制备：生化与精细结构研究
J Cell Biol. 1969 Dec;43(3):506-20. doi: 10.1083/jcb.43.3.506.
5
Effects of aminooxyacetate on the metabolism of isolated liver cells.氨基氧乙酸对分离肝细胞代谢的影响。
Arch Biochem Biophys. 1974 Apr 2;161(2):638-46. doi: 10.1016/0003-9861(74)90348-8.
6
The metabolic significance of anion transport in mitochondria.线粒体中阴离子转运的代谢意义。
Biochim Biophys Acta. 1974 Dec 30;346(3-4):213-44. doi: 10.1016/0304-4173(74)90001-9.
7
8
Effect of ornithine and lactate on urea synthesis in isolated hepatocytes.鸟氨酸和乳酸对分离肝细胞中尿素合成的影响。
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