Cornell N W, Crow K E, Whitefoot R P
Biochem J. 1981 Jul 15;198(1):219-23. doi: 10.1042/bj1980219.
Experiments with isolated rat hepatocytes and with cell extracts indicate, in contrast with previous reports, that pyruvate does not block or reverse the inhibition of aspartate aminotransferase (EC 2.6.1.1) by amino-oxyacetate. That inhibition, however, is partially overcome by glutamate or aspartate either in cell extracts or in whole cells incubated with substrate combinations that cause accumulation of those amino acids.
与之前的报道相反，对分离的大鼠肝细胞和细胞提取物进行的实验表明，丙酮酸不会阻止或逆转氨基氧乙酸对天冬氨酸转氨酶（EC 2.6.1.1）的抑制作用。然而，无论是在细胞提取物中，还是在用导致这些氨基酸积累的底物组合孵育的完整细胞中，谷氨酸或天冬氨酸都能部分克服这种抑制作用。
