Tsang I K, Patterson C A, Stein H B, Robinson H S, Ford D K
Arthritis Rheum. 1977 Mar;20(2):666-70. doi: 10.1002/art.1780200205.
Forty-four patients with definite or classic rheumatoid arthritis and failure to tolerate or respond to gold therapy were treated with D-penicillamine on a so-called go-slow, go-low regime. Seventeen patients tolerated the drug and had a 3-13 month follow-up assessment; 8 were markedly improved, 6 moderately or slightly improved, and 3 unimproved. Penicillamine had to be discontinued in 9 patients because of toxic side effects.
44例确诊或典型类风湿性关节炎患者，因不能耐受金疗法或对金疗法无反应，采用所谓的缓慢、低剂量方案接受青霉胺治疗。17例患者耐受该药物，并接受了3至13个月的随访评估；其中8例显著改善，6例中度或轻度改善，3例无改善。9例患者因毒性副作用不得不停用青霉胺。
