Mann G V
Atherosclerosis. 1977 Mar;26(3):335-40. doi: 10.1016/0021-9150(77)90086-7.
Large dietary intakes of yogurt are found to lower cholestermia in man. This effect is associated with a reduction of incorporation of radioacetate into serum cholesterol. The effect appears slowly and persists after intake of the yogurt stops suggesting that the mechanism involves the synthesis of a regulatory protein rather than an allosteric effect. The effective agent is postulated to be hydroxymethyl glutarate which inhibits the regulatory enzyme hydroxymethyl glutaryl CoA reductase (EC 1.1.1.3.4).
研究发现，大量摄入酸奶可降低人体胆固醇水平。这种效应与放射性乙酸盐掺入血清胆固醇的减少有关。该效应出现缓慢，且在停止摄入酸奶后仍持续存在，这表明其机制涉及一种调节蛋白的合成，而非变构效应。据推测，有效成分是羟甲基戊二酸，它可抑制调节酶羟甲基戊二酰辅酶A还原酶（EC 1.1.1.3.4）。
