Mikes A, Ferencík M, Jahnová E, Ebringer L, Ciznár I
Department of Geriatrics, Faculty of Medicine, Bratislava, Slovakia.
Folia Microbiol (Praha). 1995;40(6):639-46. doi: 10.1007/BF02818522.
Lyophilized Enterococcus faecium M-74 was administered to 12 adult subjects in a daily oral dose of 5 x 10(9) bacteria for six weeks. The bacterium temporarily colonized the host intestine and its excretion with stool persisted for five weeks after the last does. The mean levels of serum cholesterol and LDL showed a a biphasic effect--an elevation followed by a sharp decrease (on day 64 of investigation). The decrease corresponded in time with a significant increase in the ability to reduce iodonitrotetrazolium and superoxide production by peripheral neutrophils incubated with zymosan or phorbol myristate acetate, and also with an elevated production of IgG by peripheral blood mononuclear cells. Hence, intake of E. faecium may have a hypocholesterolemic and immunostimulatory effect. It was also demonstrated that E. faecium significantly reduced the average activity of beta-D-glucuronidase in stools.
将冻干的屎肠球菌M-74以每日口服剂量5×10⁹个细菌给予12名成年受试者，持续六周。该细菌暂时定植于宿主肠道，在最后一剂后其随粪便排出持续了五周。血清胆固醇和低密度脂蛋白的平均水平呈现双相效应——先是升高，随后急剧下降（在研究的第64天）。这种下降在时间上与用酵母聚糖或佛波酯肉豆蔻酸酯孵育的外周中性粒细胞还原碘硝基四氮唑的能力及超氧化物产生的显著增加相对应，也与外周血单核细胞产生IgG的增加相对应。因此，摄入屎肠球菌可能具有降胆固醇和免疫刺激作用。还证明屎肠球菌显著降低了粪便中β-D-葡萄糖醛酸酶的平均活性。
