Kubosawa H, Matsuzaki O, Kondo Y, Takao M, Sato N
Department of Pathology, School of Medicine, Chiba University, Japan.
Acta Pathol Jpn. 1993 Apr;43(4):209-14. doi: 10.1111/j.1440-1827.1993.tb01134.x.
A unique case of carcinosarcoma of the prostate occurring in a 32 year old man is presented. This is the youngest case reported to date among nine well-documented examples. The patient underwent a total prostatectomy under the diagnosis of prostatic sarcoma. Despite adjuvant chemotherapy and full-dose radiotherapy being undertaken, the patient died from multiple lung metastases about 8 months after the operation. The surgically resected primary tumor was composed of two histologically distinct elements, these being an undifferentiated carcinoma and a sarcoma with various mesodermal components. These elements were intimately intermingled and transitional forms were often noticed. The sarcomatous portion contained myxoid areas, spindle cell sarcomas with nuclear palisading, areas of osteoid formation and small islands of chondromatous differentiation. The pathogenesis of this complex neoplasm is discussed, and it is suggested that vestigial embryologic Müllerian mesodermal tissue may be capable of diverse differentiation.
本文报道了一例发生在一名32岁男性身上的前列腺癌肉瘤罕见病例。这是迄今为止九个有充分文献记载的病例中报道的最年轻病例。该患者在被诊断为前列腺肉瘤后接受了全前列腺切除术。尽管进行了辅助化疗和全剂量放疗，但患者在术后约8个月死于多处肺转移。手术切除的原发肿瘤由两种组织学上不同的成分组成，即未分化癌和具有各种中胚层成分的肉瘤。这些成分紧密混合，经常可见过渡形式。肉瘤部分包含黏液样区域、核呈栅栏状排列的梭形细胞肉瘤、类骨形成区域和软骨化生小灶。本文讨论了这种复杂肿瘤的发病机制，并提出残留的胚胎苗勒中胚层组织可能具有多种分化能力。
