Cusi D, Tripodi G, Casari G, Robba C, Bollini P, Merati G, Bianchi G
Department of Nephrology, Dialysis and Hypertension, Ospedale San Raffaele, Milan, Italy.
Am J Kidney Dis. 1993 May;21(5 Suppl 2):2-9. doi: 10.1016/0272-6386(93)70092-d.
Little is known of the genetics of glomerular damage in essential hypertension in humans. The prevalence of end-stage renal disease due to primary hypertension varies from 20% to 30% of all cases of renal failure to as low as 0.002%. This depends not only on differences in diagnostic criteria but also on different racial susceptibility to the disease as well as on different genetic backgrounds in different subsets of individuals of the same race. A review of the literature is provided, together with an example of how a point mutation that causes hypertension in Milan hypertensive rats can provide a model to analyze this issue correctly.
关于人类原发性高血压中肾小球损伤的遗传学，人们所知甚少。原发性高血压导致的终末期肾病在所有肾衰竭病例中的患病率从20%至30%不等，低至0.002%。这不仅取决于诊断标准的差异，还取决于不同种族对该疾病的易感性以及同一种族不同个体亚组的不同遗传背景。本文提供了文献综述，并举例说明了导致米兰高血压大鼠患高血压的点突变如何能为正确分析这一问题提供一个模型。
