Nunes E V, McGrath P J, Quitkin F M, Stewart J P, Harrison W, Tricamo E, Ocepek-Welikson K
Depression Evaluation Service, New York State Psychiatric Institute, NY 10032.
Am J Psychiatry. 1993 Jun;150(6):963-5. doi: 10.1176/ajp.150.6.963.
Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded with improvement in both mood and drinking behavior, and eight (13%) responded after further dosage increases or treatment with disulfiram. In a subsequent 6-month, randomized discontinuation trial, four of 13 subjects (31%) relapsed during imipramine treatment and seven of 10 (70%) relapsed while taking placebo. This suggests a potential treatment approach for a high-risk subgroup of alcoholics.
在完成丙咪嗪开放试验的60名抑郁酗酒者中，27人（45%）在情绪和饮酒行为方面均有改善，8人（13%）在进一步增加剂量或接受双硫仑治疗后有反应。在随后的6个月随机停药试验中，13名服用丙咪嗪的受试者中有4人（31%）复发，10名服用安慰剂的受试者中有7人（70%）复发。这表明了一种针对酗酒高危亚组的潜在治疗方法。
