Cominos D, Strutton G, Busmanis I
Department of Anatomical Pathology, Royal Brisbane Hospital, Australia.
Am J Dermatopathol. 1993 Apr;15(2):114-7. doi: 10.1097/00000372-199304000-00003.
Two patients developed localized nodular reactions at the site of prior tetanus toxoid injections. Histology of the lesions showed granuloma formation with central granular debris surrounded by a histiocytic mantle. Peripheral to this was a dense lymphoid infiltrate with eosinophils. Examination with energy dispersive x-ray microanalysis confirmed the presence of aluminium and phosphorus in the granular debris but not in the surrounding infiltrate.
两名患者在先前破伤风类毒素注射部位出现局部结节反应。病变组织学显示形成肉芽肿，中央有颗粒状碎屑，周围有组织细胞包绕。其外周是密集的淋巴细胞浸润并伴有嗜酸性粒细胞。能量色散X射线微量分析检查证实颗粒状碎屑中存在铝和磷，而周围浸润组织中不存在。
