线粒体呼吸因二磷酸腺苷而解偶联。
Uncoupling of mitochondrial respiration by ADP.
作者信息
Out T A, Krab K, Kemp A, Slater E C
出版信息
Biochim Biophys Acta. 1977 Mar 11;459(3):612-6. doi: 10.1016/0005-2728(77)90061-5.
PMID:849439
Abstract
Even when oxidative phosphorylation is blocked completely by addition of high concentrations of oligomycin plus aurovertin, the addition of ADP to a suspension of mitochondria containing a high concentration of ATP inside the mitochondria induces a stimulation of respiration and oxidation of nicotinamide nucleotide. It is concluded that transport of ADP into mitochondria with a high endogenous ATP/ADP ratio requires energy.
摘要
即使通过添加高浓度的寡霉素和金雀花碱完全阻断氧化磷酸化，向线粒体内含有高浓度ATP的线粒体悬液中添加ADP也会诱导呼吸刺激和烟酰胺核苷酸的氧化。由此得出结论，将ADP转运到具有高内源性ATP/ADP比率的线粒体中需要能量。
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