[用于抗细菌和真菌的亚胺鎓化合物。29. 3-烷氧基甲基-1-乙基-、3-烷硫基甲基-1-乙基-、3-烷氧基甲基-1-丁基-和3-烷硫基甲基-1-丁基苯并咪唑鎓氯化物]
[Iminium compounds against bacteria and fungi. 29. 3-Alkoxymethyl-1-ethyl-, 3-alkylthiomethyl-1-ethyl-, 3-alkoxymethyl-1-butyl-, and 3-alkylthiomethyl-1-butylbenzimidazolium chloride].
作者信息
Pernak J, Skrzypczak A, Michalak L, Jedraszczyk J, Krysiński J, Kazmierczak M, Mrówczyński B
机构信息
Institut für Chemische Technologie der Technischen Universität, Poznań, Polen.
出版信息
Arch Pharm (Weinheim). 1993 Apr;326(4):237-40. doi: 10.1002/ardp.19933260411.
Syntheses and antimicrobial activity of 3-alkoxymethyl-1-ethyl-, 3-alkylthiomethyl-1-ethyl-, 3-alkoxymethyl-1-butyl-, and 3-alkylthiomethyl-1-butylbenzimidazolium chlorides are described. The compounds were obtained by reaction of 1-ethyl- or 1-butylbenzimidazole with chloromethylalkyl ethers or chloromethylalkyl sulfide. Antibacterial properties were tested on 13 strains of bacteria and fungi. 3-Dodecylthio-methyl-1-ethyl-benzimidazolium chloride exhibited the highest antibacterial activity.
描述了3-烷氧基甲基-1-乙基、3-烷基硫甲基-1-乙基、3-烷氧基甲基-1-丁基和3-烷基硫甲基-1-丁基苯并咪唑鎓氯化物的合成及其抗菌活性。这些化合物通过1-乙基或1-丁基苯并咪唑与氯甲基烷基醚或氯甲基烷基硫化物反应制得。对13种细菌和真菌菌株测试了抗菌性能。3-十二烷基硫甲基-1-乙基苯并咪唑鎓氯化物表现出最高的抗菌活性。
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