复发性流产患者的多囊卵巢及促性腺激素和雄激素水平：50例女性的前瞻性研究

Polycystic ovaries and levels of gonadotrophins and androgens in recurrent miscarriage: prospective study in 50 women.

作者信息

Tulppala M, Stenman U H, Cacciatore B, Ylikorkala O

机构信息

Department II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.

出版信息

Br J Obstet Gynaecol. 1993 Apr;100(4):348-52. doi: 10.1111/j.1471-0528.1993.tb12978.x.

DOI:10.1111/j.1471-0528.1993.tb12978.x

PMID:8494836

Abstract

OBJECTIVE

To compare the serum levels of gonadotrophins and androgens, as well as ovarian morphology, in 50 women with a history of recurrent miscarriage and in 20 healthy controls.

DESIGN

Prospective study on women with a history of at least three consecutive miscarriages in Department I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Finland.

RESULTS

The recurrent miscarriage group as a whole exhibited gonadotrophin and androgen levels comparable to those seen in the controls. Ultrasound examination revealed polycystic ovaries (PCO) in 22 patients (44%) and in four control women (20%, P = 0.06) but no differences in the levels of gonadotrophins and androgens emerged between the patients with or without PCO. During follow up, 33 (66%) women with a history of recurrent miscarriage who became pregnant; 16 miscarried again (48.5%), whereas 17 (51.5%) succeeded. The presence of PCO did not predict miscarriage, but the patients who miscarried had higher levels of total testosterone, free testosterone and dehydroepiandrosterone sulphate than RSA women with continuing pregnancies.

CONCLUSIONS

PCO and hyperandrogenism may be associated with repeated miscarriage.

摘要

目的

比较50例有复发性流产病史的女性与20例健康对照者的促性腺激素和雄激素血清水平以及卵巢形态。

设计

在芬兰赫尔辛基大学中心医院妇产科一、二科对有至少连续三次流产病史的女性进行前瞻性研究。

结果

复发性流产组总体促性腺激素和雄激素水平与对照组相当。超声检查发现22例患者（44%）和4例对照女性（20%，P = 0.06）有多囊卵巢（PCO），但有无PCO的患者之间促性腺激素和雄激素水平无差异。在随访期间，33例（66%）有复发性流产病史的女性怀孕；16例再次流产（48.5%），而17例（51.5%）成功妊娠。PCO的存在不能预测流产，但流产患者的总睾酮、游离睾酮和硫酸脱氢表雄酮水平高于持续妊娠的复发性流产女性。