Wada I, Matson P L, Troup S A, Lieberman B A
Manchester Fertility Services, BUPA Hospital, Whalley Range, UK.
Br J Obstet Gynaecol. 1993 Apr;100(4):365-9. doi: 10.1111/j.1471-0528.1993.tb12981.x.
To compare the outcome of in vitro fertilisation (IVF) and gamete intrafallopian transfer (GIFT) cycles in women with or without ultrasound features of polycystic ovary syndrome (PCOS).
A consecutive series from January to December 1989.
Twenty-five women with PCOS scheduled for assisted conception. The controls were 139 women with normal ovaries.
A single centre specialist fertility unit, Manchester, UK.
Pituitary desensitisation was with buserelin. In the PCOS group ovarian stimulation was with 1 ampoule (75 iu FSH) of hMG/day in 12 women (Group I) and two ampoules/day in 13 (Group II). The controls (Group III) were given two ampoules of hMG daily. Human chorionic gonadotrophin (hCG; 10,000 iu) was given when three follicles measured > or = 20 mm diameter.
Serum oestradiol (E2) concentrations, number of follicles, clinical pregnancies, features of the ovarian hyperstimulation syndrome (OHS).
Women with PCOS (Groups I or II) had more follicles > or = 14 mm diameter on the day of the hCG injection (P < 0.005), higher serum E2 concentrations on the day after the hCG (P < 0.05) and more oocytes retrieved (P < 0.05) than the controls. The OHS was more prevalent in those with PCOS (32% versus 6.5%; P < 0.05). The clinical pregnancy rate per embryo transfer (27% versus 22%) or gamete transfer (25% versus 39%) and the rate of spontaneous miscarriage (33% versus 12%) were not statistically different.
The pregnancy rate and outcome of pregnancy following IVF or GIFT in women with or without PCOS are similar. Women with PCOS are at a higher risk of developing OHS.
比较有无多囊卵巢综合征（PCOS）超声特征的女性体外受精（IVF）和配子输卵管内移植（GIFT）周期的结局。
1989年1月至12月的连续系列研究。
25例计划进行辅助受孕的PCOS女性。对照组为139例卵巢正常的女性。
英国曼彻斯特的一个单中心专科生育单位。
使用布舍瑞林进行垂体脱敏。PCOS组中，12例女性（I组）每天使用1支（75国际单位促卵泡激素）人绝经期促性腺激素（hMG）进行卵巢刺激，13例女性（II组）每天使用2支。对照组（III组）每天给予2支hMG。当三个卵泡直径≥20毫米时，给予人绒毛膜促性腺激素（hCG；10,000国际单位）。
血清雌二醇（E2）浓度、卵泡数量、临床妊娠情况、卵巢过度刺激综合征（OHS）的特征。
PCOS女性（I组或II组）在注射hCG当天直径≥14毫米的卵泡更多（P<0.005），hCG注射后一天血清E2浓度更高（P<0.05），回收的卵母细胞更多（P<0.05）。OHS在PCOS患者中更常见（32%对6.5%；P<0.05）。每次胚胎移植（27%对22%）或配子移植（25%对39%）的临床妊娠率以及自然流产率（33%对12%）在统计学上无差异。
有无PCOS的女性在IVF或GIFT后的妊娠率及妊娠结局相似。PCOS女性发生OHS的风险更高。
