Walsh J P
Ethel Percy Andrus Gerontology Center, USC Program in Neurosciences, University of Southern California, Los Angeles 90089-0191.
Brain Res. 1993 Apr 9;608(1):123-8. doi: 10.1016/0006-8993(93)90782-i.
Intracellular recording of rat striatal neurons was performed in vitro to investigate posttetanic changes in the excitatory post-synaptic potential (EPSP) elicited by stimulation of the corpus callosum. Tetanic stimulation induced posttetanic potentiation (PTP) in 11 of 12 cells. The PTP decayed in 1-5 min and was followed by either a short or long duration depression of the EPSP in 10 of 12 neurons. The remaining two neurons examined showed a slight enhancement of the EPSP that lasted for 30 min after the tetanus. The group of cells demonstrating short-duration depression (n = 3) were characterized by a decay of the depression to the control level by 15-20 min post-tetanus. The EPSP in the remaining cells showing depression (n = 7) showed a maintained depression for the entire recording session. Blockade of GABAA receptors with bicuculline (30 microM) or NMDA receptors with APV (50 microM) did not effect the induction of long-lasting depression of the striatal EPSP. The data indicates that the corticostriatal pathway can undergo enduring forms of use-dependent synaptic plasticity. This type of synaptic modification may participate in the refinement of movement and contribute to striatal related learning and memory.
在体外对大鼠纹状体神经元进行细胞内记录，以研究刺激胼胝体引起的兴奋性突触后电位（EPSP）的强直后变化。强直刺激在12个细胞中的11个中诱导了强直后增强（PTP）。PTP在1 - 5分钟内衰减，随后12个神经元中的10个出现EPSP的短期或长期抑制。其余两个被检查的神经元在破伤风后显示EPSP轻微增强，持续30分钟。表现出短期抑制的细胞组（n = 3）的特征是，在破伤风后15 - 20分钟，抑制衰减至对照水平。其余表现出抑制的细胞（n = 7）的EPSP在整个记录过程中保持抑制。用荷包牡丹碱（30微摩尔）阻断GABAA受体或用APV（50微摩尔）阻断NMDA受体并不影响纹状体EPSP的持久抑制的诱导。数据表明，皮质纹状体通路可以经历持久形式的使用依赖性突触可塑性。这种类型的突触修饰可能参与运动的精细化，并有助于与纹状体相关的学习和记忆。
