Zoltoski R K, Velazquez-Moctezuma J, Shiromani P J, Gillin J C
Department of Psychiatry, Veterans Administration Medical Center, La Jolla, CA 92093.
Brain Res. 1993 Apr 16;608(2):186-90. doi: 10.1016/0006-8993(93)91457-4.
Three muscarinic antagonists, scopolamine, trihexyphenidyl and biperiden were systemically administered (0, 0.5, 1, 2 and 4 mg/kg) in rats. Scopolamine increased wakefulness and deceased sleep, both slow wave and REM. Trihexyphenidyl increased wakefulness and decreased REM sleep while biperiden decreased REM sleep selectively. The rank order REM-suppressing effect was roughly scopolamine and trihexyphenidyl having a greater suppressing effect than biperiden. These results suggest that the regulation of the sleep-wake cycle is at least partially controlled by the M1 muscarinic receptor.
向大鼠系统给予三种毒蕈碱拮抗剂，即东莨菪碱、苯海索和安克痉（剂量分别为0、0.5、1、2和4毫克/千克）。东莨菪碱增加觉醒并减少慢波睡眠和快速眼动睡眠。苯海索增加觉醒并减少快速眼动睡眠，而安克痉则选择性地减少快速眼动睡眠。抑制快速眼动睡眠作用的强弱顺序大致为东莨菪碱和苯海索的抑制作用强于安克痉。这些结果表明，睡眠-觉醒周期的调节至少部分受M1毒蕈碱受体控制。
