Department of Neurology, Vanderbilt University, Nashville, TN, USA.
Nat Sci Sleep. 2011 Dec 1;3:125-33. doi: 10.2147/NSS.S18897. Print 2011.
Sleep disturbances are among the most common nonmotor complaints of patients with Parkinson's disease (PD), and can have a great impact on quality of life. These disturbances manifest in a variety of ways; for instance, insomnia, sleep fragmentation, and excessive daytime sleepiness. Sleep-related movement disorders such as restless legs syndrome and periodic leg movements may share a common pathophysiology, and occurrence of rapid eye movement behavior disorder may predate the onset of PD or other synucleinopathies by several years. Medications for PD can have a significant impact on sleep, representing a great challenge to the treating physician. Awareness of the complex relationship between PD and sleep disorders, as well as the varied way in which sleep disturbances appear, is imperative for successful long-term management.
睡眠障碍是帕金森病（PD）患者最常见的非运动性主诉之一，会对生活质量产生重大影响。这些障碍表现为多种形式，例如失眠、睡眠片段化和日间过度嗜睡。睡眠相关运动障碍，如不宁腿综合征和周期性肢体运动障碍，可能具有共同的病理生理学基础，而快速眼动行为障碍的发生可能会在 PD 或其他突触核蛋白病出现前数年。PD 的治疗药物对睡眠有重大影响，这对治疗医生来说是一个巨大的挑战。了解 PD 与睡眠障碍之间的复杂关系，以及睡眠障碍出现的各种方式，对于成功的长期管理至关重要。
