Marek P, Mogil J S, Belknap J K, Sadowski B, Liebeskind J C
Department of Psychology, University of California, Los Angeles 90024.
Brain Res. 1993 Apr 16;608(2):353-7. doi: 10.1016/0006-8993(93)91479-c.
Two independent selective breeding programs have developed divergent lines of mice expressing either high and low swim stress-induced analgesia (HA/LA lines; Jastrzebiec, Poland) or high and low levorphanol analgesia (HAR/LAR lines; Portland, OR). In the present study, mice from both programs were tested for both levorphanol analgesia (2 mg/kg) and an opioid-mediated swim stress-induced analgesia (3 min swimming in 32 degrees C water) in the hot-plate test. Mice selected for high and low levorphanol analgesia displayed high and low swim stress-induced analgesia, respectively; mice selected for high and low swim stress-induced analgesia displayed high and low levorphanol analgesia, respectively. This pattern of correlated responses suggests a high degree of common genetic determination in opiate and swim stress-induced analgesia. These findings also suggest that individual differences in analgesic responsiveness to opiate drugs result from genetically determined individual differences in endogenous pain inhibitory mechanisms.
两个独立的选择性育种项目培育出了不同品系的小鼠，分别表现出高和低的游泳应激诱导镇痛能力（HA/LA品系；波兰雅斯特热别茨）或高和低的左啡诺镇痛能力（HAR/LAR品系；俄勒冈州波特兰）。在本研究中，对来自这两个项目的小鼠进行了热板试验，测试它们对左啡诺的镇痛能力（2毫克/千克）以及阿片类药物介导的游泳应激诱导镇痛能力（在32摄氏度水中游泳3分钟）。选择具有高和低左啡诺镇痛能力的小鼠分别表现出高和低的游泳应激诱导镇痛能力；选择具有高和低游泳应激诱导镇痛能力的小鼠分别表现出高和低的左啡诺镇痛能力。这种相关反应模式表明，阿片类药物和游泳应激诱导镇痛存在高度的共同遗传决定因素。这些发现还表明，对阿片类药物镇痛反应的个体差异是由内源性疼痛抑制机制中基因决定的个体差异导致的。
