Taniguchi D K, Martin R W, Trowers E A, Dennis M B, Odegaard S, Silverstein F E
Department of Medicine, University of Washington, Seattle 98195.
Gastrointest Endosc. 1993 Mar-Apr;39(2):146-52. doi: 10.1016/s0016-5107(93)70054-1.
We have developed a miniaturized ultrasound device that attaches to the gastrointestinal mucosa by suction and produces high-resolution (+/- 0.1 mm) images of the layers of the intestinal wall. The esophageal wall layers in a single sheep were measured during 20 occlusive contractions observed with simultaneous endoscopy, which revealed thickening of the inner circular muscle layer from 1.2 +/- 0.2 mm to 2.2 +/- 0.4 mm (p < 0.01), and during 20 dilations demonstrating thinning of the full thickness of the esophageal wall from 3.6 +/- 0.3 mm to 2.9 +/- 0.3 mm (p < 0.01). Safety experiments performed in two canine stomachs demonstrated no erosions or ulceration at any level of suction. Our investigations indicate that the M-mode suction ultrasound device can safely assess changes occurring in the layers of the esophageal wall during contractions and dilations and should be evaluated for the study of human intestinal motility.
我们研发了一种小型超声设备，它通过吸力附着于胃肠道黏膜，并能生成肠壁各层的高分辨率（±0.1毫米）图像。在用同步内窥镜观察的20次闭塞性收缩过程中，对一只绵羊的食管壁各层进行了测量，结果显示内环肌层厚度从1.2±0.2毫米增厚至2.2±0.4毫米（p<0.01）；在20次扩张过程中，食管壁全层厚度从3.6±0.3毫米变薄至2.9±0.3毫米（p<0.01）。在两只犬的胃部进行的安全性实验表明，在任何吸力水平下均未出现糜烂或溃疡。我们的研究表明，M型吸力超声设备能够安全地评估食管壁各层在收缩和扩张过程中发生的变化，应进一步评估其用于人体肠道蠕动研究的价值。
