Nadal D, Lauener R P, Braegger C P, Kaufhold A, Simma B, Lütticken R, Seger R A
Division of Immunology/Hematology, University Children's Hospital, Zurich, Switzerland.
J Pediatr. 1993 May;122(5 Pt 1):727-9. doi: 10.1016/s0022-3476(06)80014-4.
A 5-year-old girl with streptococcal toxic shock-like syndrome during varicella infection had high levels of tumor necrosis factor alpha and interleukin-6 but no interleukin-1 or interleukin-2 in the serum. Intravenous administration of gamma-globulin coincided with clinical improvement and with reduction of the levels of tumor necrosis factor alpha and interleukin-6. The data suggest that streptococcal pyrogenic exotoxins trigger synthesis of tumor necrosis factor alpha and interleukin-6 in vivo; intravenously administered gamma-globulin may down-regulate the cytokine response.
一名5岁患水痘感染期间并发链球菌中毒性休克样综合征的女孩，血清中肿瘤坏死因子α和白细胞介素-6水平升高，但白细胞介素-1和白细胞介素-2水平正常。静脉注射丙种球蛋白后临床症状改善，同时肿瘤坏死因子α和白细胞介素-6水平降低。这些数据提示，链球菌致热外毒素在体内可触发肿瘤坏死因子α和白细胞介素-6的合成；静脉注射丙种球蛋白可能会下调细胞因子反应。
