Echevarria F A, Armour J, Bairden K, Duncan J L
Department of Veterinary Parasitology, University of Glasgow.
J S Afr Vet Assoc. 1993 Mar;64(1):31-4.
Worm-free lambs (n = 6) were infected with 5,000 L3 of an ivermectin/benzimidazole/closantel resistant strain of Haemonchus contortus. On Day 21 post infection animals were allocated, according to worm egg counts, to 2 groups of 3 animals each and on Day 29 one group was treated with albendazole at 3.8 mg kg-1, while animals in the other group remained untreated as controls. All animals were slaughtered on Day 44 when the treated group was found to have 2,083 +/- 1,718 worms and the controls 2,783 +/- 633, a reduction of 25.2% in worm burdens. The pattern of egg output was monitored and it was found that 2 d after dosing, worm egg counts had been suppressed by 89% in the treated group; thereafter the egg counts increased, but never returned to the pretreatment levels and by Day 15 post treatment, they were still 41.1% lower in the treated group than in the controls.
无蠕虫羔羊（n = 6）感染了5000条对伊维菌素/苯并咪唑/氯氰碘柳胺耐药的捻转血矛线虫L3幼虫。感染后第21天，根据虫卵计数将动物分为两组，每组3只。在第29天，一组动物以3.8 mg kg-1的剂量接受阿苯达唑治疗，而另一组动物作为对照不进行治疗。所有动物在第44天宰杀，此时治疗组的蠕虫数量为2083±1718条，对照组为2783±633条，蠕虫负荷减少了25.2%。监测了产卵模式，发现给药后2天，治疗组的虫卵计数被抑制了89%；此后虫卵计数增加，但从未恢复到治疗前水平，在治疗后第15天，治疗组的虫卵计数仍比对照组低41.1%。
