Schnyder M, Torgerson P R, Schönmann M, Kohler L, Hertzberg H
Institute of Parasitology, University of Zurich, Winterthurerstrasse 266a, CH-8057 Zurich, Switzerland.
Vet Parasitol. 2005 Mar 31;128(3-4):285-90. doi: 10.1016/j.vetpar.2004.12.010. Epub 2005 Jan 25.
A suspected case of multiple anthelmintic resistance on a farm in the canton of Zurich, Switzerland, into which South African Boer goats had previously been imported, was confirmed in a controlled test. Twenty sheep were allocated into one control group and three treatment groups to determine the efficacy of mebendazole, ivermectin and moxidectin applying the faecal egg count reduction test (FECRT). The sheep were slaughtered 1 week later and post-mortem worm counts were performed. Benzimidazole and ivermectin resistance were found in Haemonchus contortus with an efficacy of 55 and 61%, respectively. Moxidectin appeared to be effective when the data was analysed according to the recommended analytical techniques with an efficacy of 96%. This is the first description of resistance of gastrointestinal nematodes to one of the macrocyclic lactones in small ruminants in Switzerland. The results are discussed in relation to the importance of controlling livestock before importation.
瑞士苏黎世州一个农场出现多药抗蠕虫疑似病例，该农场此前曾引进南非布尔山羊，经对照试验确诊。将20只绵羊分为1个对照组和3个治疗组，采用粪便虫卵计数减少试验（FECRT）来确定甲苯咪唑、伊维菌素和莫昔克丁的疗效。1周后宰杀绵羊并进行死后蠕虫计数。捻转血矛线虫对苯并咪唑和伊维菌素有抗性，疗效分别为55%和61%。按照推荐的分析技术分析数据时，莫昔克丁似乎有效，疗效为96%。这是瑞士首次报道小反刍动物胃肠道线虫对大环内酯类药物之一产生抗性。结合进口前控制牲畜的重要性对结果进行了讨论。
