Jacobson L S, Jardine J E
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
J S Afr Vet Assoc. 1993 Mar;64(1):47-51.
Neospora caninum is a recently identified protozoan parasite which was previously confused with Toxoplasma gondii. Neosporosis in puppies commonly causes signs referable to parasitic encephalomyelitis and myositis. The parasite was identified in tissues from 3 9-week-old Labrador littermates which showed signs of progressive hind limb hyperextension and paralysis. The diagnosis was confirmed, utilising a specific avidin-biotin immunohistochemical technique. Attempts to treat the pups with clindamycin were unsuccessful. One case was additionally treated with immunosuppressive doses of corticosteroids, but showed no improvement. Two pups were euthanased and necropsied. The predominant lesions were polymyositis and multifocal encephalomyelitis. Large clusters of tachyzoites were seen in the myofibres and thick-walled parasitic tissue cysts were found in the grey and white matter of the brain and spinal cord.
犬新孢子虫是一种最近才被鉴定出来的原生动物寄生虫，以前曾与刚地弓形虫混淆。幼犬的新孢子虫病通常会引发与寄生虫性脑脊髓炎和肌炎相关的症状。在3只9周大的拉布拉多同窝幼犬的组织中发现了这种寄生虫，这些幼犬表现出进行性后肢过度伸展和麻痹的症状。利用一种特定的抗生物素蛋白-生物素免疫组织化学技术确诊了该病。尝试用克林霉素治疗这些幼犬但未成功。其中一只幼犬还接受了免疫抑制剂量的皮质类固醇治疗，但并无改善。两只幼犬实施了安乐死并进行了尸检。主要病变为多发性肌炎和多灶性脑脊髓炎。在肌纤维中可见大量速殖子簇，在脑和脊髓的灰质和白质中发现了厚壁的寄生组织囊肿。
