镰状基因：血压的一个标志物？
The sickle gene: a marker for blood pressure?
作者信息
Adams-Campbell L L, Nwankwo M U, Ukoli F A, Biu T
机构信息
Division of Epidemiology and Cancer Control, Howard University Cancer Center, Washington, DC 20060.
出版信息
J Natl Med Assoc. 1993 May;85(5):385-7.
Blood pressure patterns were studied in 224 Nigerians comprising 22 families with at least one child with sickle cell anemia (SS) and 18 families without sickle cell anemia (AA) in a community with a high frequency of the sickle trait (AS). Among the offspring (n = 162; mean age: 10.1 years), systolic blood pressure did not differ between the SS, AS, or AA groups. However, the SS group had significantly lower diastolic blood pressure than the AS or AA groups (60.6 versus 66.5 and 65.4 mm Hg, respectively; P < .01). After controlling for genotype, age, body mass index, and sex, regression analysis revealed that age was the only independent correlate of blood pressure.
在一个镰状性状（AS）高发的社区中，对224名尼日利亚人进行了血压模式研究，其中包括22个家庭，每个家庭至少有一个患有镰状细胞贫血（SS）的孩子，以及18个没有镰状细胞贫血（AA）的家庭。在后代（n = 162；平均年龄：10.1岁）中，SS、AS或AA组之间的收缩压没有差异。然而，SS组的舒张压显著低于AS或AA组（分别为60.6与66.5和65.4 mmHg；P < .01）。在控制了基因型、年龄、体重指数和性别后，回归分析显示年龄是血压的唯一独立相关因素。
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