Akodu Samuel Olufemi, Diaku-Akinwumi Ijeoma Nnenna, Kehinde Omolara Adeolu, Njokanma Olisamedua Fidelis
a Department of Pediatrics , Lagos State University Teaching Hospital , Ikeja , Lagos , NIGERIA.
J Am Coll Nutr. 2014;33(6):437-41. doi: 10.1080/07315724.2013.875356. Epub 2014 Jun 25.
Sickle cell anemia may affect linear growth, and complications like avascular necrosis of femoral head may make direct measurement of height difficult.
To determine the relationship between height and arm span as well as between height and sitting height among children with sickle cell anemia in Lagos, Nigeria.
A random sample of 200 children aged 8 months to 15 years were studied-100 with hemoglobin genotype SS and 100 with hemoglobin genotype AA, matched for age and sex. Height/length, sitting height, and arm span were measured. Correlations and regression analysis were performed to test the relationship between height as a dependent variable and the sitting height and arm span as independent variables.
Height, arm span, and sitting height were slightly but not significantly lower in subjects with sickle cell anemia. Strong correlations (R ≥ 0.95) were observed between height and other measurements in both subgroups. Regression analysis with height as the independent variable showed that arm span had a higher coefficient of determination than sitting height in both subjects (R(2) = 0.94 vs 0.899) and controls (R(2) = 0.942 vs 0.940). On the other hand, sitting height had a lower mean difference between observed and predicted height (0.04 and -0.11, respectively).
Sitting height may be the preferred proxy for height in children with sickle cell anemia.
镰状细胞贫血可能影响线性生长，而股骨头缺血性坏死等并发症可能使身高的直接测量变得困难。
确定尼日利亚拉各斯镰状细胞贫血患儿身高与臂展以及身高与坐高之间的关系。
对200名年龄在8个月至15岁的儿童进行随机抽样研究，其中100名血红蛋白基因型为SS，100名血红蛋白基因型为AA，按年龄和性别匹配。测量身高/身长、坐高和臂展。进行相关性和回归分析，以检验作为因变量的身高与作为自变量的坐高和臂展之间的关系。
镰状细胞贫血患者的身高、臂展和坐高略低，但差异不显著。在两个亚组中，身高与其他测量值之间均观察到强相关性（R≥0.95）。以身高为自变量的回归分析表明，在患者（R² = 0.94对0.899）和对照组（R² = 0.942对0.940）中，臂展的决定系数均高于坐高。另一方面，坐高的观察值与预测值之间的平均差异较小（分别为0.04和-0.11）。
坐高可能是镰状细胞贫血患儿身高的首选替代指标。
