Ward M J
Asthma Education Unit, King's Mill Hospital, Sutton-in-Ashfield, Nottinghamshire, U.K.
Respir Med. 1993 Feb;87 Suppl A:33-5; discussion 35-6. doi: 10.1016/s0954-6111(05)80255-0.
Asthmatic patients receiving long-term therapy with oral prednisolone have been found to have an increased incidence of vertebral fractures. Measurements of bone density have shown that diminished bone density is associated with administration of oral corticosteroids rather than with the disease. Inhaled corticosteroids have some systemic activity and although serum calcium and parathyroid hormone levels are unaffected by corticosteroids, inhaled corticosteroids at doses of more than 1.0 mg day-1 have measurable effects on bone metabolism in normal subjects.
已发现接受口服泼尼松龙长期治疗的哮喘患者椎体骨折发生率增加。骨密度测量表明，骨密度降低与口服皮质类固醇的使用有关，而非与疾病本身相关。吸入性皮质类固醇具有一定的全身活性，虽然血清钙和甲状旁腺激素水平不受皮质类固醇影响，但每日剂量超过1.0毫克的吸入性皮质类固醇对正常受试者的骨代谢有可测量的影响。
