Julius M, Maroun C R, Haughn L
Dept of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Immunol Today. 1993 Apr;14(4):177-83. doi: 10.1016/0167-5699(93)90282-p.
The co-ordinated interactions of multiple membrane molecules with the T-cell receptor for antigen (the TCR-CD3) are prerequisite for T-cell activation. In this review we consider the involvement of CD4, CD8, and CD45 on the two lymphocyte lineages. Experiments from many laboratories have provided concordant results leading to the consensus that CD4 and CD8 are functional analogues, providing similar supplementary signals to those generated through the TCR-CD3 complex on MHC class-II- and MHC class-I-restricted T cells, respectively. However, recent results demonstrate striking differences in the coreceptor functions of CD4 and CD8. These differences reflect the distinct properties of the molecules themselves, which in turn are associated with CD45 involvement in the activation of CD4+ and CD8+ T cells.
多种膜分子与抗原T细胞受体（TCR-CD3）的协同相互作用是T细胞活化的先决条件。在本综述中，我们考虑了CD4、CD8和CD45在两种淋巴细胞谱系中的作用。许多实验室的实验得出了一致的结果，形成了这样的共识：CD4和CD8是功能类似物，分别为MHC II类和MHC I类限制性T细胞上通过TCR-CD3复合物产生的信号提供类似的辅助信号。然而，最近的结果表明CD4和CD8的共受体功能存在显著差异。这些差异反映了分子本身的独特特性，而这些特性又与CD45参与CD4+和CD8+T细胞的活化有关。
